If you were to ask a group of people why brain cancer would rise to the surface, the various answers given will show that there is no concrete reasoning. Enzymes could play a role in the matter, as it's been said that they can trigger and make this condition progress. This is especially true when focusing on glioblastoma, the most common and aggressive type of cancer in this regard. Focusing on enzymes, though, what can be done in order to stop them in their tracks?
Futurity put forth a report that spoke about a method that could help for this purpose. The report in question referred to it as a "backdoor" approach in order to help brain cancer and one of its potential triggers. It's possible that an enzyme related to glioblastoma can be stopped, which is a great point to consider when looking at organizations like Voices against Brain Cancer. Not all of the details are clear, though, which is why a learning experience is more than helpful here.
The enzyme in particular that was looked at was given the name of phospholipase D, though it isn't relevant to brain cancer alone. In fact, it is one that has been focused on while focusing on cancers the likes of breast and gastric. It's apparent that PLD has been given a tremendous amount of focus but another point to take into account is how it was able to regulate Akt. For those who are unaware, Akt is an enzyme that also plays into the growth of cancer.
PLD was given a tremendous amount of focus during a study with mice, each of the subjects afflicted with glioblastoma. One would assume that simply locking Akt would aid the problem but, as the article detailed, it is a course of action that stands a great chance of creating strong actions in the body. An exaggerated immune response, for example, could come to the surface. This subject deserves focus, without question, but care is another element that shouldn't be ignored.
According to Professor Craig Lindsley, as the article stated, it is possible to modulate the one isoform associated with Akt without bringing harm to the patient. Without Akt being activated in the body, the cancerous cells in the body die, which does not negatively impact the patient in question in any way. This is especially vital in this field of research. As long as the implications do not long-lasting results, I do not think that anyone can argue with the level of potential seen here.
Futurity put forth a report that spoke about a method that could help for this purpose. The report in question referred to it as a "backdoor" approach in order to help brain cancer and one of its potential triggers. It's possible that an enzyme related to glioblastoma can be stopped, which is a great point to consider when looking at organizations like Voices against Brain Cancer. Not all of the details are clear, though, which is why a learning experience is more than helpful here.
The enzyme in particular that was looked at was given the name of phospholipase D, though it isn't relevant to brain cancer alone. In fact, it is one that has been focused on while focusing on cancers the likes of breast and gastric. It's apparent that PLD has been given a tremendous amount of focus but another point to take into account is how it was able to regulate Akt. For those who are unaware, Akt is an enzyme that also plays into the growth of cancer.
PLD was given a tremendous amount of focus during a study with mice, each of the subjects afflicted with glioblastoma. One would assume that simply locking Akt would aid the problem but, as the article detailed, it is a course of action that stands a great chance of creating strong actions in the body. An exaggerated immune response, for example, could come to the surface. This subject deserves focus, without question, but care is another element that shouldn't be ignored.
According to Professor Craig Lindsley, as the article stated, it is possible to modulate the one isoform associated with Akt without bringing harm to the patient. Without Akt being activated in the body, the cancerous cells in the body die, which does not negatively impact the patient in question in any way. This is especially vital in this field of research. As long as the implications do not long-lasting results, I do not think that anyone can argue with the level of potential seen here.
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If you'd like to learn more about efforts to elevate awareness for brain cancer, please visit Voices against Brain Cancer.
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